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dc.contributor.authorSigaeva, Taisiya
dc.contributor.authorSattari, Samaneh
dc.contributor.authorPolzer, Stanislav
dc.contributor.authorAppoo, Jehangir J.
dc.contributor.authorDi Martino, Elena S.
dc.date.accessioned2021-10-27T13:39:11Z
dc.date.available2021-10-27T13:39:11Z
dc.date.issued2021
dc.identifier.citationJournal of Biomechanics. 2021, vol. 125, art. no. 110542.cs
dc.identifier.issn0021-9290
dc.identifier.issn1873-2380
dc.identifier.urihttp://hdl.handle.net/10084/145360
dc.description.abstractThis study investigates the biomechanical properties of ascending aortic aneurysms focusing on the inter-patient differences vs. the heterogeneity within a patient's aneurysm. Each specimen was tested on a biaxial testing device and the resulting stress-strain response was fitted to a four-parameter Fung constitutive model. We postulate that the inter-patient variability (differences between patients) blurs possible intra-patient variability (regional heterogeneity) and, thus, that both effects must be considered to shed light on the role of heterogeneity in aneurysm progression. We propose, demonstrate, and discuss two techniques to assess differences by, first, comparing conventional biomechanical properties and, second, the overall constitutive response. Results show that both inter-and intra-patient variability contribute to errors when using population averaged models to fit individual tissue behaviour. When inter-patient variability was accounted for and its effects excluded, intra-patient heterogeneity could be assessed, showing a wide degree of heterogeneity at the individual patient level. Furthermore, the right lateral region (from the patient's perspective) appeared different (stiffer) than the other regions. We posit that this heterogeneity could be a consequence of maladaptive remodelling due to altered loading conditions that hastens microstructural changes naturally occurring with age. Further validation of these results should be sought from a larger cohort study.cs
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofseriesJournal of Biomechanicscs
dc.relation.urihttps://doi.org/10.1016/j.jbiomech.2021.110542cs
dc.rights© 2021 Elsevier Ltd. All rights reserved.cs
dc.subjectbiaxial testingcs
dc.subjectregional variabilitycs
dc.subjectcircumferential regionscs
dc.subjectintra-patient variabilitycs
dc.subjectinter-patient variabilitycs
dc.subjectascending thoracic aortacs
dc.subjectaneurysmscs
dc.subjectFung modelcs
dc.subjecttangent modulics
dc.titleBiomechanical properties of ascending aortic aneurysms: Quantification of inter- and intra-patient variabilitycs
dc.typearticlecs
dc.identifier.doi10.1016/j.jbiomech.2021.110542
dc.type.statusPeer-reviewedcs
dc.description.sourceWeb of Sciencecs
dc.description.volume125cs
dc.description.firstpageart. no. 110542cs
dc.identifier.wos000685352700007


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