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dc.contributor.authorMaliňák, David
dc.contributor.authorDoležal, Rafael
dc.contributor.authorMarek, Jan
dc.contributor.authorSalajková, Šárka
dc.contributor.authorSoukup, Ondřej
dc.contributor.authorVejsová, Marcela
dc.contributor.authorKorábečný, Jan
dc.contributor.authorHonegr, Jan
dc.contributor.authorPenhaker, Marek
dc.contributor.authorMusílek, Kamil
dc.contributor.authorKuča, Kamil
dc.date.accessioned2015-02-06T12:31:30Z
dc.date.available2015-02-06T12:31:30Z
dc.date.issued2014
dc.identifier.citationBioorganic & Medicinal Chemistry Letters. 2014, vol. 24, issue 22, s. 5238-5241.cs
dc.identifier.issn0960-894X
dc.identifier.issn1464-3405
dc.identifier.urihttp://hdl.handle.net/10084/106388
dc.description.abstractQuaternary ammonium salts substituted with a long alkyl chain exemplify a trustworthy group of medicinal compounds frequently employed as antifungal and antibacterial agents. A great asset of these surfactants underlying their widespread use is low local and system toxicity in humans. In this Letter, a series of novel quaternary 6-hydroxyquinolinium salts with varying length of N-alkyl chain (from C10 to C18) was synthesized and tested for in vitro activity against pathogenic bacterial and fungal strains. 6-Hydroxyquinolinium salt with C12 alkyl chain seems to be very interesting candidate due to a high antimicrobial efficacy and cytotoxic safety.cs
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofseriesBioorganic & Medicinal Chemistry Letterscs
dc.relation.urihttp://dx.doi.org/10.1016/j.bmcl.2014.09.060cs
dc.title6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activitycs
dc.typearticlecs
dc.identifier.doi10.1016/j.bmcl.2014.09.060
dc.type.statusPeer-reviewedcs
dc.description.sourceWeb of Sciencecs
dc.description.volume24cs
dc.description.issue22cs
dc.description.lastpage5241cs
dc.description.firstpage5238cs
dc.identifier.wos000343901400021


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